In New Mexico, the Pueblo peoples, led by Popé, coordinated an uprising against the Spanish at dozens of settlements across hundreds of miles. The Indians destroyed buildings and churches and killed more than 400 Spaniards. They burned Sante Fe and drove the Spanish back to El Paso. While the Pueblo Revolt was the most successful effort by American Indians to drive out European settlers from their lands, the Spanish were back in twelve years.
Popé was a seventeenth-century Pueblo religious leader who led the Pueblo Revolt, the most successful American Indian uprising ever. In 1680, Popé led the Pueblo in attacking the Spanish. Though the revolt was successful in pushing the Spanish out of New Mexico, the region was reconquered again by Spain, soon after Popé’s death, in 1692.