John White returned to Roanoke with more English colonists to find the settlement deserted. The settlers there may have moved on or been attacked by American Indians, but their fate was never confirmed, leaving Roanoke’s abandonment a mystery.
Native American populations in New England, with no immunity to European diseases, were nearly eradicated by a mysterious epidemic—likely smallpox. Between 1616 and 1619, the population of the Massachusett and other Algonquin tribes was reduced by as much as 90 percent by disease.
The Iroquois and the Dutch entered into a mutually beneficial alliance, wherein the Dutch found success in fur-trading and the Iroqouis gained access to goods and weapons.
Virginia Dare became the first English child born in North America, at Roanoke.
The first American Indian reservations were established when Puritans, led by John Davenport and Theophilus Eaton, signed a treaty dividing lands near New Haven with the Quinnipiac Indians.
Reverend Thomas Hooker and a group of settlers from Massachusetts established Hartford.